Juq-139 [verified] Review

Male CD‑1 mice (n = 3 per time point) received a single oral dose of JUQ‑139 (30 mg kg⁻¹) formulated in 0.5 % methylcellulose. Plasma samples were collected at 0.25, 0.5, 1, 2, 4, 8, and 24 h, processed by protein precipitation, and analyzed by LC‑MS/MS (LLOQ = 5 ng mL⁻¹). Non‑compartmental analysis (Phoenix WinNonlin) yielded the following PK parameters: C max = 2.4 µg mL⁻¹, T max = 1 h, AUC₀–∞ = 15 µg·h mL⁻¹, t½ = 6.8 h, oral bioavailability ≈ 45 %.

As the mystery surrounding JUQ-139 continues to grow, several theories have emerged: JUQ-139