Zeb Atlas Full Free -

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| Developmental Process | ZEB Expression Pattern | Functional Insight | |------------------------|------------------------|--------------------| | (zebrafish 12–24 hpf) | ZEB2 high in premigratory crest; ZEB1 low. | ZEB2 directly activates Sox10 and Snai2 , establishing a neural‑crest‑specific EMT program (validated by CRISPR knockout). | | Somitogenesis (mouse E8.5–E10.5) | Transient ZEB1 expression in the paraxial mesoderm . | ChIP‑seq shows ZEB1 binding to Hox cluster enhancers, modulating somite patterning. | | Heart Valve Morphogenesis (zebrafish 48–72 hpf) | ZEB1/2 co‑expressed in endocardial cells undergoing EMT. | Loss of ZEB1 results in valve stenosis; scRNA‑seq reveals failure to up‑regulate Nfatc1 . | zeb atlas full

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