The film follows two ambitious genetic engineers, Clive Nicoli (played by ) and Elsa Kast ( Sarah Polley ), who secretly conduct an experiment to create a human-animal hybrid.
Released during the transitional summer of 2009—a season dominated by Star Trek and Transformers: Revenge of the Fallen — arrived like a scalpel to the jugular of mainstream cinema. It was not a superhero origin story nor a sequel to a toy commercial. Instead, it was a cold, clinical fable about parental hubris, genetic consequences, and the terrifying intimacy of playing God. --Splice-2009----
Clive and Elsa rushed to the tank. The creature inside was thrashing. The amniotic fluid was turning cloudy. The film follows two ambitious genetic engineers, Clive