The Rise of Cobra tells the origin of the G.I. Joe team—an international covert operations unit using advanced technology (like the infamous Accelerator Suits). The plot follows Duke (Channing Tatum) and Ripcord (Marlon Wayans) as they attempt to retrieve nanomite warheads, only to clash with the mysterious Baroness (Sienna Miller), Destro (Christopher Eccleston), and the masked mercenary known as Snake Eyes.