Yumino Rimu - My Childhood Friend Has Royd-155 ... -

In the context of adult-themed narratives (often categorized under "plot-heavy" themes), "ROYD-155" likely refers to a fictional setting where:

The emotional labor of caring is visible in small acts: rescheduling an appointment, dialing a phone at three in the morning, sitting through a looped story for the twentieth time. The economic and social labor is less visible but no less real. Friends trade hours; one keeps a spreadsheet of medications, another manages paperwork for disability benefits. In a town where resources are sparse, they rely on a patchwork of clinics and online support groups. Yumino Rimu - My Childhood Friend Has ROYD-155 ...

or a mainstream manga involving childhood friends, you might be interested in I Think I Turned My Childhood Friend into a Girl In the context of adult-themed narratives (often categorized