(2004) : In her Telugu debut, Mukherjee played Roopa, an independent woman who chooses self-respect over a toxic relationship with her wealthy fiancé. The film's romance with the character Anand (played by Raja) is noted for its realistic approach, where the characters prioritize getting to know each other over "love at first sight".
is the character closest to her real-life spontaneous personality. Vettaiyaadu Vilaiyaadu (2006) – Kayalvizhi kamalini mukherjee first lip kiss and sex exclusive
However, the paradigm shift came with the Bengali adaptation of Parineeta (2005) directed by Debaki Kumar Bose. Playing the gentle, resilient Lalita opposite Indraneil Sengupta, Kamalini established the template for her romantic heroines: the woman who loves silently but fiercely. Critics noted that her first major romantic arcs were defined by a "restrained yearning"—a trait that would make her a sensation when she crossed over to the South. (2004) : In her Telugu debut, Mukherjee played