Gvg-526 Mother-to-child Adolescence Hatano Yui %7cverified%7c Jun 2026

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| Section | Main Points | |---------|-------------| | | • GVG‑526 is a newly identified viral vector associated with vertical (mother‑to‑child) transmission. • Prior work suggested possible neurodevelopmental effects, but data on adolescent outcomes were lacking. | | Objectives | 1. Quantify the rate of GVG‑526 transmission from pregnant carriers to neonates. 2. Assess cognitive, behavioral, and endocrine markers in the offspring at ages 12‑18. | | Methods | • Design: Prospective cohort (n = 312 mother‑infant dyads) followed from birth to age 18. • Exposure Assessment: PCR detection of GVG‑526 RNA in maternal blood, placenta, cord blood, and infant serum. • Outcome Measures: – Cognitive function (WISC‑V, WAIS‑IV). – Behavioral screening (CBCL, Youth Self‑Report). – Hormonal profiling (cortisol, LH/FSH, IGF‑1). • Statistical Analyses: Mixed‑effects models controlling for socioeconomic status, maternal health, and co‑infections. | | Results | • Transmission Rate: 23 % (71/312) of infants tested positive for GVG‑526 at birth. • Adolescent Findings (n = 68 GVG‑526‑positive vs. 244 negative): – Cognitive scores: Average Full‑Scale IQ 5‑7 points lower in the positive group (p = 0.012). – Behavioral outcomes: Higher incidence of internalizing problems (OR = 2.1, 95 % CI 1.3‑3.4). – Endocrine markers: Elevated basal cortisol (≈ 15 % increase) and altered pubertal timing (earlier menarche in females, p = 0.03). | | Interpretation | The authors argue that vertical transmission of GVG‑526 is not merely a transient infection; it appears to have lasting neuro‑endocrine sequelae that manifest during adolescence. They suggest a possible mechanistic link via chronic low‑grade inflammation affecting the hypothalamic‑pituitary‑adrenal axis. | | Limitations | • Cohort limited to a single geographic region (urban Japan). • Potential residual confounding by unmeasured environmental toxins. • No longitudinal viral load data beyond birth (i.e., re‑activation). | | Conclusions & Recommendations | • Routine screening for GVG‑526 in pregnant women could be considered in high‑prevalence settings. • Early intervention programs (cognitive support, stress‑management) may mitigate adverse outcomes. • Further research needed on antiviral prophylaxis and the biological pathways involved. | | Funding & Conflicts | Funded by the Japanese Ministry of Health, Labour and Welfare and a grant from the Global Virology Initiative. No declared conflicts of interest. | | | Objectives | 1

Adolescence is a critical period of growth and development, marked by significant physical, emotional, and psychological changes. Media representations of adolescents and their relationships with parents or parental figures can vary widely, influencing or reflecting societal views on these relationships. Assess cognitive, behavioral, and endocrine markers in the

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